Lab Achievements

2/11/2025, ORS 2025 (Phoenix, AZ)

• Thrombospondin-2 mediates the neuro-angiogenic transcriptome in post-traumatic osteoarthritic synovium. (Lindsey Lammlin, et. al.)

2/10/2025, ORS 2025 (Phoenix, AZ) - NIRA Award

• Integrated Analysis of Human Synovium Transcriptomics Data Implicates Macrophage-Driven Neuro-Immune Signaling Mediated by STAT1 in Osteoarthritis (Mike Newton, et. al.)

2/10/2025, ORS 2025 (Phoenix, AZ)

• Integrative Lineage Tracing Reveals Multipotency of Synovial 𝛼SMA+ Cells in Post-Traumatic Osteoarthritis (Aanya Mohan)

2/9/2025, ORS 2025 (Phoenix, AZ)

• PIEZO1 promotes synovial fibrosis and inflammation (Easton Farrell, et. al.)

2/9/2025, ORS 2025 (Phoenix, AZ)

• Spatial Transcriptomic Atlas of PTOA Synovium (Helen Tran)

2/8/2025, ORS 2025 (Phoenix, AZ)

• Distinct crosstalk, mechanosensitization, and transcription factors define synovial macrophage identity in the DMM model of osteoarthritis (Easton Farrell, et. al.)

8/4/2024, Musculoskeletal Biology and Bioengineering Gordon Research Seminar (Andover, NH)

• A novel role for CXCL16 in synovial inflammation and joint nociception (Lindsey Lammlin, et. al.)

8/3/2024, Musculoskeletal Biology and Bioengineering Gordon Research Seminar (Andover, NH)

• Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis. (Lindsey Lammlin, et. al.)

6/6/2024, Physiology Graduate Research Symposium (Ann Arbor, MI)

• A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)

4/18/2024, OARSI 2024 World Congress on Osteoarthritis (Vienna, Austria)

• Mapping the Joint-Nerve Interactome of the Knee: An Integrative Approach for Identifying New Strategies for the Control of Joint Pain (Anne-Marie Malfait, et. al.)

4/9/2024, AIMM/ASBMR meeting (Snowmass, CO)

• Osteophyte formation in post-traumatic osteoarthritis. (Alexander Knights, et. al.)

  • John Haddad YI award

2/3/2024, ORS 2024 (Long Beach, CA) - NIRA Award

• Wnt signaling underpins fibro-adipogenic dynamics of intra-articular fat during post-traumatic osteoarthritis (Alexander Knights, et. al.)

3/18/2023, Cartilage Biology and Pathology Gordon Research Seminar (Lucca, Italy)

• Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et al.)

2/14/2023, ORS 2023 (Dallas, TX)

• Molecular mapping of CXCR4 expression by articular chondrocytes following joint injury (Micheal Newton, et. al.)

• Piezo1-driven myofibroblast emergence in post-traumatic osteoarthritis (Easton Farrell, et. al.)

• Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et. al.)

5/17/2022, MiMHC Annual Musculoskeletal Health Symposium 2022 (Ann Arbor, MI)

• CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)

5/12/2022, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)

• Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alexander Knights, et. al.)

4/7/2022, OARSI World Congress 2022 (Berlin, Germany)

• Synovial and Subchondral Bone Neuroplasticity in Four Mouse Models of Knee Osteoarthritis (Alia Obeidat et. al.)

2/8/2022, ORS Annual Meeting 2022 (Tampa, FL)

• Synovial Single Cell Profiling Reveals A Functional Fibroblast Hierarchy In Post-traumatic Osteoarthritis (Alexander Knights, et. al.)

• CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)

• Loss Of Thrombospondin-2 Alters Synovial Inflammation, Cartilage Integrity, And Bone Composition (Lucas Junginger, et. al.)

2/12/2021, ORS Annual Meeting 2021 (Virtual)

• The Wnt agonist R-spondin 2 promotes joint degeneration in post-traumatic osteoarthritis (Alexander Knights, et. al.)

4/30/2020, OARSI World Congress 2020 (Vienna, Austria)

• Pain, Inflammation, and the Endocannabinoid System in Murine Post-Traumatic Osteoarthritis (Phillip Rzeczycki, et. al.)

2/8/2020, ORS Annual Meeting 2020 (Phoenix, AZ)

• Local And Systemic Effects Of Ischemic Therapy In A Rat Model (Austin Ramme, et. al.)

• Characterization Of The Nociceptive, Inflammatory, And Endocannabinoid System Response In A Mouse Model Of ACL Rupture-induced Post-traumatic Osteoarthritis (Phillip Rzeczycki, et. al.)

8/12/2019, ORS Great Lakes 2019 (Chicago, IL)

• Intraarticular Chemokine Expression Following Anterior Cruciate Ligament Rupture: Implications for Injury-Induced Mesenchymal Stem Cell Recruitment (Stephen Redding, et. al.)

8/6/2018, ORS Great Lakes 2018 (Ann Arbor, MI)

• Automated MicroCT-based Bone and Articular Cartilage Analysis Using Iterative Shape Averaging and Atlas-Based Registration (Lucas Junginger, et. al.)

12/11/2024, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)

• A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)

11/13/2024, Center for Cell Plasticity and Organ Design (CPOD) 14th International Symposium (Ann Arbor, MI)

• A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)

10/2/2024, Program in Biomedical Sciences 25th Anniversary Symposium (Ann Arbor, MI)

• A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)

8/3/2024, Musculoskeletal Biology and Bioengineering Gordon Research Conference and Seminar (Andover, NH)

• Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis. (Lindsey Lammlin, et. al.)

• Wnt signaling underpins fibro-adipogenic dynamics of intra-articular fat during post-traumatic osteoarthritis. (Alexander Knights, et. al.)

6/6/2024, Physiology Graduate Research Symposium (Ann Arbor, MI)

• A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)

• Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis. (Lindsey Lammlin, et. al.)

5/16/2024, MiMHC 8th Annual Musculoskeletal Health Symposium (Ann Arbor, MI)

• Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis. (Lindsey Lammlin, et. al.)

4/4/2024, ACTS 2024 (Las Vegas, NV)

• Targeting Cdk8 to improve ischemic fracture healing (Christina Capobianco, et. al.)

2/4/2024, ORS 2024 (Long Beach, CA)

• Osteoarthritic Synovium and Systemic Sclerosis Skin Share Conserved Fibroblast Transcriptome Patterns (Micheal Newton, et. al.)

• Wnt signaling underpins fibro-adipogenic dynamics of intra-articular fat during post-traumatic osteoarthritis (Alexander Knights, et. al.)

• Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis (Lindsey Lammlin, et. al.)

12/14/2023, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)

• Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis (Lindsey, Lammlin, et. al.)

11/6/2023, RE-JOIN Consortium Annual Meeting (Houston, TX)

• Mobile Joint Operator (MoJO): A Low-Cost, Highly Reproducible Platform for Noninvasive Knee Joint Injury (Micheal Newton, et. al.)

10/05/2023, “Great Minds, Greater Discoveries” Dean’s Lecture (Ann Arbor, MI)

• Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis (Lindsey Lammlin, et. al.)

9/22/2023, Carl E. Badgley Day Lectureship (Ann Arbor, MI)

• Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis (Lindsey Lammlin, et. al.)

5/11/2023, MSK 2023 (Ann Arbor)

• Piezo1-driven synovial fibrosis in post-traumatic osteoarthritis (Easton Farrell, et. el.)

• Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et. al.)

3/20/23, Cartilage Biology and Pathology Gordon Research Conference (Lucca, Italy)

• Emergence of osteochondral precursors in synovium following joint injury (Alexander Knights, et. al.)

• Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et. al.)

2/14/2023, ORS 2023 (Dallas, TX)

• Stromal-immune crosstalk via CSF signaling orchestrates synovial macrophage speciation in post-traumatic osteoarthritis (Alexander Knights, et. al.)

• Sex- and model-dependent transcriptomic differences of the dorsal root ganglion in osteoarthritis (Easton Farrell, et. al.)

9/23/2022, Carl E. Badgley Day Lectureship (Ann Arbor, MI)

• Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et. al.)

• Piezo1-driven myofibroblast emergence in post-traumatic osteoarthritis (Easton Farrell, et. al.)

• Identification of distinct functional subsets of synovial fibroblasts in osteoarthritis (Alexander Knights, et. al.)

8/10/2022, Gordon MSK Conference 2022 (Andover, NH)

• Synovial stromal-immune crosstalk mechanisms in post-traumatic osteoarthritis  (Alexander Knights, et. al.)

7/18/2022, FASEB Matricellular Proteins Conference 2022  (Lisbon, Portugal)

• Thrombospondin-1 and -2 ablation causes aberrant angiogenesis, inflammation, and knee joint remodeling (Lindsey Lammlin, et. al.)

• An Absence of CD47 Leads to Impaired Bone Healing in the Early Fracture Callus (Christina Capobianco, et. al.)

5/18/2022, Glenn V. Edmonson Lecture and 2022 Biomedical Engineering Symposium (Ann Arbor, MI)

• Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.) 

  • Poster winner

• Pathologic Myofibroblast Emergence in Post-Traumatic Osteoarthritis (Easton Farrell, et. al.) 

  • Poster winner

5/17/2022, MiMHC Annual Musculoskeletal Health Symposium 2022 (Ann Arbor, MI)

• Automated MicroCT-based Trabecular Bone Analysis Using Convolutional Neural Networks (Haneef Khan, et. al.)

• CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)

• Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alex Knights, et. al.)

• Immune Cell Dynamics During Early Fracture Healing (Michelle Song, et. al.)

• Profiling the Immune Landscape of the Synovium in Post-Traumatic Osteoarthritis (Olivia Ellis, et. al.)

• Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.)

5/12/2022, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)

• CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)

  • Third place poster award

• Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alex Knights, et. al.)

• Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.)

5/19/2021, MiMHC Annual Musculoskeletal Health Symposium 2021 (Ann Arbor, MI)

• The Chemotactic and Cell Specific Roles of CXCL16 Following Joint Injury (Lindsey Lammlin, et. al.)

5/1/2021, OARSI World Congress 2021 (Virtual)

• Pain-, Tissue Degeneration-, and Synovial Transcriptome-based Sex Differences in Murine Post-traumatic Osteoarthritis (Rachel Bergman, et. al.)

7/11/2020, AOSSM 2020 (Seattle, WA)

• An Assessment of Hip Strength, Patient Reported Outcomes, and Plasma Inflammatory Biomarkers After Surgical Correction for Symptomatic Femoroacetabular Impingement (Maxwell Konnaris, et. al.)

2/8/2020, ORS Annual Meeting 2020 (Phoenix, AZ)

• Thrombospondin-2, An Endogenous Anti-angiogenic Protein, Is Strongly Expressed By The Synovium Following Traumatic Injury In Mice (Lucas Junginger, et. al.)

• An Assessment Of Hip Strength, Patient Reported Outcomes, And Plasma Inflammatory Biomarkers After Surgical Correction For Symptomatic Femoroacetabular Impingement (Maxwell Konnaris, et. al.)

• Intraarticular CXCL16 Expression Following Anterior Cruciate Ligament Rupture: Implications For Injury-Induced Mesenchymal Stem Cell Recruitment In Post-Traumatic Osteoarthritis (Stephen Redding, et. al.)

8/12/2019, ORS Great Lakes 2019 (Chicago, IL)

• Thrombospondin 2, an endogenous anti angiogenic protein, is strongly expressed by the synovium following traumatic joint injury in mice (Lucas Junginger et. al)

• Improvement in Hip Strength and Patient Reported Outcomes of Pain and Function Are Independent of Changes in Inflammatory Biomarkers After Surgical Correction of Femoroacetabular Impingement (Maxwell Konnaris, et. al.)

• Characterization of the Nociceptive and Inflammatory Response in a Mouse Model of ACL Rupture (Phillip Rzeczycki, et. al.)

7/9/2019, AOSSM 2019 (Boston, MA)

• Local And Systemic Effects Of Ischemic Therapy In A Rat Model (Austin Ramme, et. al.)

2/5/2019, ORS Annual Meeting 2019 (Austin, TX)

• Automated MicroCT-based Bone and Articular Cartilage Analysis Using Iterative Shape Averaging and Atlas-Based Registration (Michael Newton, et. al.)