Lab Achievements

Recent Publications

Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 to drive osteoarthritis

Knights, A., Farrell, E., Ellis, O., Lammlin, L., Junginger, L., Rzeczycki, P., Bergman, R., Pervez, R., Cruz, M., Samani, A., Wu, C., Hankenson, K., Maerz, T.

bioRxiv, 2022.05.06.489035

https://doi.org/10.1101/2022.05.06.489035

Cannabinoid receptor type 2 is upregulated in synovium following joint injury and mediates anti-inflammatory effects in synovial fibroblasts and macrophages

Rzeczycki, P., Rasner, C., Lammlin, L., Junginger, L., Goldman, S., Bergman, R., Redding, S., Knights, A.J., Elliott, M. and Maerz, T.

Osteoarthritis and Cartilage, 29(12), pp.1720-1731.

https://doi.org/10.1016/j.joca.2021.09.003

Podium Presentations

  • 5/17/2022, MiMHC Annual Musculoskeletal Health Symposium 2022 (Ann Arbor, MI)

    • CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)

  • 5/12/2022, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)

    • Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alex Knights, et. al.)

  • 4/7/2022, OARSI World Congress 2022 (Berlin, Germany)

    • Synovial and Subchondral Bone Neuroplasticity in Four Mouse Models of Knee Osteoarthritis (Alia Obeidat et. al.)

  • 2/8/2022, ORS Annual Meeting 2022 (Tampa, FL)

    • Synovial Single Cell Profiling Reveals A Functional Fibroblast Hierarchy In Post-traumatic Osteoarthritis (Alex Knights, et. al.)

    • CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)

    • Loss Of Thrombospondin-2 Alters Synovial Inflammation, Cartilage Integrity, And Bone Composition (Lucas Junginger, et. al.)

  • 2/12/2021, ORS Annual Meeting 2021 (Virtual)

    • The Wnt agonist R-spondin 2 promotes joint degeneration in post-traumatic osteoarthritis (Alex Knights, et. al.)

  • 4/30/2020, OARSI World Congress 2020 (Vienna, Austria)

    • Pain, Inflammation, and the Endocannabinoid System in Murine Post-Traumatic Osteoarthritis (Phillip Rzeczycki, et. al.)

  • 2/8/2020, ORS Annual Meeting 2020 (Phoenix, AZ)

    • Local And Systemic Effects Of Ischemic Therapy In A Rat Model (Austin Ramme, et. al.)

    • Characterization Of The Nociceptive, Inflammatory, And Endocannabinoid System Response In A Mouse Model Of ACL Rupture-induced Post-traumatic Osteoarthritis (Phillip Rzeczycki, et. al.)

  • 8/12/2019, ORS Great Lakes 2019 (Chicago, IL)

    • Intraarticular Chemokine Expression Following Anterior Cruciate Ligament Rupture: Implications for Injury-Induced Mesenchymal Stem Cell Recruitment (Stephen Redding, et. al.)

  • 8/6/2018, ORS Great Lakes 2018 (Ann Arbor, MI)

    • Automated MicroCT-based Bone and Articular Cartilage Analysis Using Iterative Shape Averaging and Atlas-Based Registration (Lucas Junginger, et. al.)

Poster Presentations

  • 5/18/2022, Glenn V. Edmonson Lecture and 2022 Biomedical Engineering Symposium (Ann Arbor, MI)

    • Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.)

      • Poster winner

    • Pathologic Myofibroblast Emergence in Post-Traumatic Osteoarthritis (Easton Farrell, et. al.)

      • Poster winner

  • 5/17/2022, MiMHC Annual Musculoskeletal Health Symposium 2022 (Ann Arbor, MI)

    • Automated MicroCT-based Trabecular Bone Analysis Using Convolutional Neural Networks (Haneef Khan, et. al.)

    • CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)

    • Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alex Knights, et. al.)

    • Immune Cell Dynamics During Early Fracture Healing (Michelle Song, et. al.)

    • Profiling the Immune Landscape of the Synovium in Post-Traumatic Osteoarthritis (Olivia Ellis, et. al.)

    • Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.)

  • 5/12/2022, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)

    • CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)

      • Third place poster award

    • Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alex Knights, et. al.)

    • Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.)

  • 5/19/2021, MiMHC Annual Musculoskeletal Health Symposium 2021 (Ann Arbor, MI)

    • The Chemotactic and Cell Specific Roles of CXCL16 Following Joint Injury (Lindsey Lammlin, et. al.)

  • 5/1/2021, OARSI World Congress 2021 (Virtual)

    • Pain-, Tissue Degeneration-, and Synovial Transcriptome-based Sex Differences in Murine Post-traumatic Osteoarthritis (Rachel Bergman, et. al.)

  • 7/11/2020, AOSSM 2020 (Seattle, WA)

    • An Assessment of Hip Strength, Patient Reported Outcomes, and Plasma Inflammatory Biomarkers After Surgical Correction for Symptomatic Femoroacetabular Impingement (Maxwell Konnaris, et. al.)

  • 2/8/2020, ORS Annual Meeting 2020 (Phoenix, AZ)

    • Thrombospondin-2, An Endogenous Anti-angiogenic Protein, Is Strongly Expressed By The Synovium Following Traumatic Injury In Mice (Lucas Junginger, et. al.)

    • An Assessment Of Hip Strength, Patient Reported Outcomes, And Plasma Inflammatory Biomarkers After Surgical Correction For Symptomatic Femoroacetabular Impingement (Maxwell Konnaris, et. al.)

    • Intraarticular CXCL16 Expression Following Anterior Cruciate Ligament Rupture: Implications For Injury-Induced Mesenchymal Stem Cell Recruitment In Post-Traumatic Osteoarthritis (Stephen Redding, et. al.)

  • 8/12/2019, ORS Great Lakes 2019 (Chicago, IL)

    • Thrombospondin 2, an endogenous anti angiogenic protein, is strongly expressed by the synovium following traumatic joint injury in mice (Lucas Junginger et. al)

    • Improvement in Hip Strength and Patient Reported Outcomes of Pain and Function Are Independent of Changes in Inflammatory Biomarkers After Surgical Correction of Femoroacetabular Impingement (Maxwell Konnaris, et. al.)

    • Characterization of the Nociceptive and Inflammatory Response in a Mouse Model of ACL Rupture (Phillip Rzeczycki, et. al.)

  • 7/9/2019, AOSSM 2019 (Boston, MA)

    • Local And Systemic Effects Of Ischemic Therapy In A Rat Model (Austin Ramme, et. al.)

  • 2/5/2019, ORS Annual Meeting 2019 (Austin, TX)

    • Automated MicroCT-based Bone and Articular Cartilage Analysis Using Iterative Shape Averaging and Atlas-Based Registration (Michael Newton, et. al.)