Lab Achievements
Recent Publications
From cartilage to culture: Opportunities for unraveling the complexities of osteoarthritis through sex and gender
Maerz, T., Schipohof, D.
Osteoarthritis and Cartilage
Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis
Knights, A., Farrell, E., Ellis, O., Song, M., Appleton, C.T., Maerz, T.
bioRXiv
Is synovitis inevitable after ACL injury?
Maerz, T.
Osteoarthritis and Cartilage
Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
Bergman, R., Lammlin, L., Junginger, L., Farrell, E., Goldman, S., Darcy, R., Rasner, C., Obeidat, A., Malfait, A., Miller, R., Maerz, T.
Osteoarthritis and Cartilage
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 to in osteoarthritis
Knights, A., Farrell, E., Ellis, O., Lammlin, L., Junginger, L., Rzeczycki, P., Bergman, R., Pervez, R., Cruz, M., Knight, E., Farmer, D., Samani, A., Wu, C., Hankenson, K., Maerz, T.
Annals of Rheumatic Diseases
Cannabinoid receptor type 2 is upregulated in synovium following joint injury and mediates anti-inflammatory effects in synovial fibroblasts and macrophages
Rzeczycki, P., Rasner, C., Lammlin, L., Junginger, L., Goldman, S., Bergman, R., Redding, S., Knights, A.J., Elliott, M. and Maerz, T.
Osteoarthritis and Cartilage, 29(12), pp.1720-1731.
Podium Presentations
8/4/2024, Musculoskeletal Biology and Bioengineering Gordon Research Seminar (Andover, NH)
A novel role for CXCL16 in synovial inflammation and joint nociception (Lindsey Lammlin, et. al.)
8/3/2024, Musculoskeletal Biology and Bioengineering Gordon Research Seminar (Andover, NH)
Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis. (Lindsey Lammlin, et. al.)
6/6/2024, Physiology Graduate Research Symposium (Ann Arbor, MI)
A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)
4/18/2024, OARSI 2024 World Congress on Osteoarthritis (Vienna, Austria)
Mapping the Joint-Nerve Interactome of the Knee: An Integrative Approach for Identifying New Strategies for the Control of Joint Pain (Anne-Marie Malfait, et. al.)
4/9/2024, AIMM/ASBMR meeting (Snowmass, CO)
Osteophyte formation in post-traumatic osteoarthritis. (Alexander Knights, et. al.)
John Haddad YI award
2/3/2024, ORS 2024 (Long Beach, CA)
Wnt signaling underpins fibro-adipogenic dynamics of intra-articular fat during post-traumatic osteoarthritis (Alexander Knights, et. al.)
3/18/2023, Cartilage Biology and Pathology Gordon Research Seminar (Lucca, Italy)
Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et al.)
2/14/2023, ORS 2023 (Dallas, TX)
Molecular mapping of CXCR4 expression by articular chondrocytes following joint injury (Micheal Newton, et. al.)
Piezo1-driven myofibroblast emergence in post-traumatic osteoarthritis (Easton Farrell, et. al.)
Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et. al.)
5/17/2022, MiMHC Annual Musculoskeletal Health Symposium 2022 (Ann Arbor, MI)
CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)
5/12/2022, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)
Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alexander Knights, et. al.)
4/7/2022, OARSI World Congress 2022 (Berlin, Germany)
Synovial and Subchondral Bone Neuroplasticity in Four Mouse Models of Knee Osteoarthritis (Alia Obeidat et. al.)
2/8/2022, ORS Annual Meeting 2022 (Tampa, FL)
Synovial Single Cell Profiling Reveals A Functional Fibroblast Hierarchy In Post-traumatic Osteoarthritis (Alexander Knights, et. al.)
CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)
Loss Of Thrombospondin-2 Alters Synovial Inflammation, Cartilage Integrity, And Bone Composition (Lucas Junginger, et. al.)
2/12/2021, ORS Annual Meeting 2021 (Virtual)
The Wnt agonist R-spondin 2 promotes joint degeneration in post-traumatic osteoarthritis (Alexander Knights, et. al.)
4/30/2020, OARSI World Congress 2020 (Vienna, Austria)
Pain, Inflammation, and the Endocannabinoid System in Murine Post-Traumatic Osteoarthritis (Phillip Rzeczycki, et. al.)
2/8/2020, ORS Annual Meeting 2020 (Phoenix, AZ)
Local And Systemic Effects Of Ischemic Therapy In A Rat Model (Austin Ramme, et. al.)
Characterization Of The Nociceptive, Inflammatory, And Endocannabinoid System Response In A Mouse Model Of ACL Rupture-induced Post-traumatic Osteoarthritis (Phillip Rzeczycki, et. al.)
8/12/2019, ORS Great Lakes 2019 (Chicago, IL)
Intraarticular Chemokine Expression Following Anterior Cruciate Ligament Rupture: Implications for Injury-Induced Mesenchymal Stem Cell Recruitment (Stephen Redding, et. al.)
8/6/2018, ORS Great Lakes 2018 (Ann Arbor, MI)
Automated MicroCT-based Bone and Articular Cartilage Analysis Using Iterative Shape Averaging and Atlas-Based Registration (Lucas Junginger, et. al.)
Poster Presentations
12/11/2024, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)
A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)
11/13/2024, Center for Cell Plasticity and Organ Design (CPOD) 14th International Symposium (Ann Arbor, MI)
A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)
10/2/2024, Program in Biomedical Sciences 25th Anniversary Symposium (Ann Arbor, MI)
A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)
8/3/2024, Musculoskeletal Biology and Bioengineering Gordon Research Conference and Seminar (Andover, NH)
Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis. (Lindsey Lammlin, et. al.)
Wnt signaling underpins fibro-adipogenic dynamics of intra-articular fat during post-traumatic osteoarthritis. (Alexander Knights, et. al.)
6/6/2024, Physiology Graduate Research Symposium (Ann Arbor, MI)
A novel role for CXCL16 in joint inflammation and nociception. (Lindsey Lammlin, et. al.)
Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis. (Lindsey Lammlin, et. al.)
5/16/2024, MiMHC 8th Annual Musculoskeletal Health Symposium (Ann Arbor, MI)
Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis. (Lindsey Lammlin, et. al.)
4/4/2024, ACTS 2024 (Las Vegas, NV)
Targeting Cdk8 to improve ischemic fracture healing (Christina Capobianco, et. al.)
2/4/2024, ORS 2024 (Long Beach, CA)
Osteoarthritic Synovium and Systemic Sclerosis Skin Share Conserved Fibroblast Transcriptome Patterns (Micheal Newton, et. al.)
Wnt signaling underpins fibro-adipogenic dynamics of intra-articular fat during post-traumatic osteoarthritis (Alexander Knights, et. al.)
Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis (Lindsey Lammlin, et. al.)
12/14/2023, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)
Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis (Lindsey, Lammlin, et. al.)
11/6/2023, RE-JOIN Consortium Annual Meeting (Houston, TX)
Mobile Joint Operator (MoJO): A Low-Cost, Highly Reproducible Platform for Noninvasive Knee Joint Injury (Micheal Newton, et. al.)
10/05/2023, “Great Minds, Greater Discoveries” Dean’s Lecture (Ann Arbor, MI)
Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis (Lindsey Lammlin, et. al.)
9/22/2023, Carl E. Badgley Day Lectureship (Ann Arbor, MI)
Thrombospondin-2 serves a time-dependent role in mediating nociceptive behavior, structural remodeling, and the synovial transcriptome in post-traumatic osteoarthritis (Lindsey Lammlin, et. al.)
5/11/2023, MSK 2023 (Ann Arbor)
Piezo1-driven synovial fibrosis in post-traumatic osteoarthritis (Easton Farrell, et. el.)
Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et. al.)
3/20/23, Cartilage Biology and Pathology Gordon Research Conference (Lucca, Italy)
Emergence of osteochondral precursors in synovium following joint injury (Alexander Knights, et. al.)
Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et. al.)
2/14/2023, ORS 2023 (Dallas, TX)
Stromal-immune crosstalk via CSF signaling orchestrates synovial macrophage speciation in post-traumatic osteoarthritis (Alexander Knights, et. al.)
Sex- and model-dependent transcriptomic differences of the dorsal root ganglion in osteoarthritis (Easton Farrell, et. al.)
9/23/2022, Carl E. Badgley Day Lectureship (Ann Arbor, MI)
Dual deficiency of thrombospondin-1 and -2 causes aberrant intra-articular angiogenesis, inflammation, and ectopic synovial bone formation (Lindsey Lammlin, et. al.)
Piezo1-driven myofibroblast emergence in post-traumatic osteoarthritis (Easton Farrell, et. al.)
Identification of distinct functional subsets of synovial fibroblasts in osteoarthritis (Alexander Knights, et. al.)
8/10/2022, Gordon MSK Conference 2022 (Andover, NH)
Synovial stromal-immune crosstalk mechanisms in post-traumatic osteoarthritis (Alexander Knights, et. al.)
7/18/2022, FASEB Matricellular Proteins Conference 2022 (Lisbon, Portugal)
Thrombospondin-1 and -2 ablation causes aberrant angiogenesis, inflammation, and knee joint remodeling (Lindsey Lammlin, et. al.)
An Absence of CD47 Leads to Impaired Bone Healing in the Early Fracture Callus (Christina Capobianco, et. al.)
5/18/2022, Glenn V. Edmonson Lecture and 2022 Biomedical Engineering Symposium (Ann Arbor, MI)
Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.)
Poster winner
Pathologic Myofibroblast Emergence in Post-Traumatic Osteoarthritis (Easton Farrell, et. al.)
Poster winner
5/17/2022, MiMHC Annual Musculoskeletal Health Symposium 2022 (Ann Arbor, MI)
Automated MicroCT-based Trabecular Bone Analysis Using Convolutional Neural Networks (Haneef Khan, et. al.)
CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)
Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alex Knights, et. al.)
Immune Cell Dynamics During Early Fracture Healing (Michelle Song, et. al.)
Profiling the Immune Landscape of the Synovium in Post-Traumatic Osteoarthritis (Olivia Ellis, et. al.)
Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.)
5/12/2022, Michigan Postdoctoral Pioneer Program Symposium (Ann Arbor, MI)
CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis (Lindsey Lammlin, et. al.)
Third place poster award
Identification of Distinct Functional Subsets of Synovial Fibroblasts in Osteoarthritis (Alex Knights, et. al.)
Stromal Cell Heterogeneity of the Early Ischemic and Intact Fracture Callus (Christina Capobianco, et. al.)
5/19/2021, MiMHC Annual Musculoskeletal Health Symposium 2021 (Ann Arbor, MI)
The Chemotactic and Cell Specific Roles of CXCL16 Following Joint Injury (Lindsey Lammlin, et. al.)
5/1/2021, OARSI World Congress 2021 (Virtual)
Pain-, Tissue Degeneration-, and Synovial Transcriptome-based Sex Differences in Murine Post-traumatic Osteoarthritis (Rachel Bergman, et. al.)
7/11/2020, AOSSM 2020 (Seattle, WA)
An Assessment of Hip Strength, Patient Reported Outcomes, and Plasma Inflammatory Biomarkers After Surgical Correction for Symptomatic Femoroacetabular Impingement (Maxwell Konnaris, et. al.)
2/8/2020, ORS Annual Meeting 2020 (Phoenix, AZ)
Thrombospondin-2, An Endogenous Anti-angiogenic Protein, Is Strongly Expressed By The Synovium Following Traumatic Injury In Mice (Lucas Junginger, et. al.)
An Assessment Of Hip Strength, Patient Reported Outcomes, And Plasma Inflammatory Biomarkers After Surgical Correction For Symptomatic Femoroacetabular Impingement (Maxwell Konnaris, et. al.)
Intraarticular CXCL16 Expression Following Anterior Cruciate Ligament Rupture: Implications For Injury-Induced Mesenchymal Stem Cell Recruitment In Post-Traumatic Osteoarthritis (Stephen Redding, et. al.)
8/12/2019, ORS Great Lakes 2019 (Chicago, IL)
Thrombospondin 2, an endogenous anti angiogenic protein, is strongly expressed by the synovium following traumatic joint injury in mice (Lucas Junginger et. al)
Improvement in Hip Strength and Patient Reported Outcomes of Pain and Function Are Independent of Changes in Inflammatory Biomarkers After Surgical Correction of Femoroacetabular Impingement (Maxwell Konnaris, et. al.)
Characterization of the Nociceptive and Inflammatory Response in a Mouse Model of ACL Rupture (Phillip Rzeczycki, et. al.)
7/9/2019, AOSSM 2019 (Boston, MA)
Local And Systemic Effects Of Ischemic Therapy In A Rat Model (Austin Ramme, et. al.)
2/5/2019, ORS Annual Meeting 2019 (Austin, TX)
Automated MicroCT-based Bone and Articular Cartilage Analysis Using Iterative Shape Averaging and Atlas-Based Registration (Michael Newton, et. al.)